Chronic endometritis is persistent inflammation of the uterine lining. It differs from endometriosis, which involves tissue similar to the uterine lining growing outside the uterus.

What are the symptoms?
Many people have no obvious symptoms. Others may experience spotting, unusual discharge or pelvic discomfort. These symptoms alone cannot confirm the diagnosis.

Can it affect fertility?
Chronic endometritis has been associated with implantation difficulties and pregnancy loss, but finding it does not prove it caused an unsuccessful pregnancy or embryo transfer.

When should testing be considered?
A fertility specialist may consider testing after repeated unsuccessful embryo transfers, following a review of other possible factors. It is not a routine test for everyone trying to conceive.

How is it diagnosed?
An endometrial biopsy checks for plasma cells, often using CD138 staining. Hysteroscopy may provide additional clues, but diagnostic criteria are not fully standardized.

Can it be treated?
Antibiotics may be considered when diagnosed. However, evidence that treatment improves pregnancy or live-birth rates remains uncertain. Testing and treatment should be individualized.

Longevity Fertility Centre | Calgary & Edmonton